abstract：IMPORTANCE:Medication persistence is an important factor for treatment effect in patients with glaucoma. Evaluating risk factors for refill discontinuation might be helpful for improving persistence and preventing blindness in patients with glaucoma. OBJECTIVES:To estimate the persistence rate with topical glaucoma me...

journal_title：JAMA ophthalmology

authors： Hwang DK,Liu CJ,Pu CY,Chou YJ,Chou P

更新日期：2014-12-01 00:00:00

abstract：IMPORTANCE:We describe a sign that can be used as a rapid and noninvasive adjunct to aid in the diagnosis of foveal hypoplasia. OBJECTIVE:To describe a concentric macular rings sign found on infrared reflectance (IRR) images in patients with foveal hypoplasia. DESIGN, SETTING, AND PATIENTS:We studied 13 patients with...

journal_title：JAMA ophthalmology

authors： Cornish KS,Reddy AR,McBain VA

更新日期：2014-09-01 00:00:00

abstract：IMPORTANCE:Although anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration (AMD) results in improved vision overall, loss of substantial vision can occur. Understanding the processes that lead to loss of vision may lead to preventive strategies. OBJECTIVE:To determine the inc...

journal_title：JAMA ophthalmology

authors： Ying GS,Kim BJ,Maguire MG,Huang J,Daniel E,Jaffe GJ,Grunwald JE,Blinder KJ,Flaxel CJ,Rahhal F,Regillo C,Martin DF,CATT Research Group.

更新日期：2014-08-01 00:00:00

abstract：IMPORTANCE:The clinical features of the follicular subtype of ocular adnexal lymphoma (OAL) have not been previously evaluated in a large cohort. OBJECTIVE:To characterize the clinical features of follicular OAL. DESIGN, SETTING, AND PARTICIPANTS:We performed a retrospective multicenter study that involved 6 eye canc...

journal_title：JAMA ophthalmology

authors： Rasmussen PK,Coupland SE,Finger PT,Graue GF,Grossniklaus HE,Honavar SG,McKelvie P,Mulay K,Prause JU,Ralfkiaer E,Sjö LD,Heegaard S

更新日期：2014-07-01 00:00:00

abstract：IMPORTANCE:Descemet stripping automated endothelial keratoplasty (DSAEK) for isolated endothelial dysfunction has become the preferred surgical option for many corneal surgeons. However, there are limited large-scale reports on DSAEK survival and clinical variables affecting the risk of rejection and failure after fail...

journal_title：JAMA ophthalmology

authors： Mitry D,Bhogal M,Patel AK,Lee BS,Chai SM,Price MO,Price FW Jr,Jun AS,Aldave AJ,Mehta JS,Busin M,Allan BD

更新日期：2014-06-01 00:00:00

abstract：IMPORTANCE:Superior rectus transposition (SRT) with or without medial rectus recession (MRc) has been introduced as an alternative to MRc alone for treatment of esotropic Duane syndrome; however, the effectiveness of these procedures has not been compared previously. OBJECTIVE:To compare the safety and efficacy of MRc...

journal_title：JAMA ophthalmology

authors： Yang S,MacKinnon S,Dagi LR,Hunter DG

更新日期：2014-06-01 00:00:00

abstract：IMPORTANCE:Schnabel cavernous degeneration (SCD) has been observed in eyes with uveal melanoma (UM), but, to our knowledge, a definitive study establishing the association between SCD and UM has not been conducted. OBJECTIVE:To explore an association between SCD and UM. DESIGN, SETTING, AND PARTICIPANTS:A historical ...

journal_title：JAMA ophthalmology

authors： Kanavi MR,Azari AA,Potter HD,Lee V,Albert DM

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To determine whether treatment of choroidal melanoma influences survival by correlating age at death, cause of death, age at treatment, and survival predictors. DESIGN, SETTING, AND PARTICIPANTS:Prospective cohort study performed at the Liverpool Ocular Oncology Centre, a supraregional, tertiary referral ser...

journal_title：JAMA ophthalmology

authors： Damato BE,Heimann H,Kalirai H,Coupland SE

更新日期：2014-05-01 00:00:00

abstract：:IMPORTANCE Advanced glycation end products have been implicated in the pathogenesis of age-related macular degeneration (AMD). OBJECTIVE To investigate the relationship between serum carboxymethyllysine (CML), a major circulating advanced glycation end product, and AMD in older adults. DESIGN, SETTING, AND PARTICIPANT...

journal_title：JAMA ophthalmology

authors： Semba RD,Cotch MF,Gudnason V,Eiríksdottir G,Harris TB,Sun K,Klein R,Jonasson F,Ferrucci L,Schaumberg DA

更新日期：2014-04-01 00:00:00

abstract：IMPORTANCE:Myopia is a significant public health problem, making it important to determine whether a bifocal spectacle treatment involving near prism slows myopia progression in children. OBJECTIVE:To determine whether bifocal and prismatic bifocal spectacles control myopia in children with high rates of myopia progre...

journal_title：JAMA ophthalmology

authors： Cheng D,Woo GC,Drobe B,Schmid KL

更新日期：2014-03-01 00:00:00

abstract：IMPORTANCE:We present a method to reintroduce ophthalmic training into the medical school curriculum. OBJECTIVES:To evaluate knowledge and skills acquired when participating in a service project, the Community Vision Project, and to develop a quantitative method for testing skills with the direct ophthalmoscope in pat...

journal_title：JAMA ophthalmology

authors： Byrd JM,Longmire MR,Syme NP,Murray-Krezan C,Rose L

更新日期：2014-03-01 00:00:00

abstract：IMPORTANCE:There is a major lack of randomized controlled clinical trials evaluating the efficacy of prismatic treatments for hemianopia. Evidence for their effectiveness is mostly based on anecdotal case reports and open-label evaluations without a control condition. OBJECTIVE:To evaluate the efficacy of real relativ...

journal_title：JAMA ophthalmology

authors： Bowers AR,Keeney K,Peli E

更新日期：2014-02-01 00:00:00

abstract：:Within 20 years of its discovery 100 years ago, vitamin A was recognized as critical to normal eyes, growth, and survival. Clinical interest subsequently contracted to its importance in preventing xerophthalmia, until this ophthalmologist stumbled, quite accidently, on its role in fighting life-threatening infections....

journal_title：JAMA ophthalmology

authors： Sommer A

更新日期：2014-01-01 00:00:00

abstract：IMPORTANCE:The CX3CR1 gene is implicated as a candidate gene for age-related macular degeneration (AMD) through several lines of evidence. There is uncertainty, however, as to whether common genetic variants in CX3CR1 alter risk of AMD, since prior studies have been inconsistent and mostly limited to evaluation of 2 no...

journal_title：JAMA ophthalmology

authors： Schaumberg DA,Rose L,DeAngelis MM,Semba RD,Hageman GS,Chasman DI

更新日期：2014-01-01 00:00:00

abstract：IMPORTANCE:This study confirmed the long-term outcomes of the ZB5M phakic intraocular lens (PIOL). OBJECTIVE:To evaluate the potential long-term risk associated with ZB5M PIOL implantation. DESIGN, SETTING, AND PARTICIPANTS:A retrospective, nonrandomized, consecutive cohort study of a total of 208 eyes implanted with...

journal_title：JAMA ophthalmology

authors： Alio JL,Abbouda A,Peña-Garcia P,Huseynli S

更新日期：2013-12-01 00:00:00

abstract：IMPORTANCE:To date, only a few studies have directly compared nonpenetrating surgery (NPS) and trabeculectomy (TE). Therefore, there is no strong evidence as to which surgical technique leads to the best results in terms of ocular hypotensive effect and safety. OBJECTIVE:To compare the hypotensive effect and safety of...

journal_title：JAMA ophthalmology

authors： Rulli E,Biagioli E,Riva I,Gambirasio G,De Simone I,Floriani I,Quaranta L

更新日期：2013-12-01 00:00:00

abstract：IMPORTANCE:Binocular summation (BiS) is defined as the superiority of visual function for binocular over monocular viewing. Binocular summation decreases with age and large interocular differences in visual acuity. To our knowledge, BiS has not heretofore been well studied as a functional measure of binocularity in str...

journal_title：JAMA ophthalmology

authors： Pineles SL,Velez FG,Isenberg SJ,Fenoglio Z,Birch E,Nusinowitz S,Demer JL

更新日期：2013-11-01 00:00:00

abstract：IMPORTANCE:Acanthamoeba keratitis is a debilitating eye disease that requires effective topical drug therapy. Currently, there is no standard in vitro test to evaluate anti-Acanthamoeba drugs. OBJECTIVE:To develop a practical in vitro complete-kill assay to assess anti-Acanthamoeba drugs. DESIGN AND SETTING:Isolates ...

journal_title：JAMA ophthalmology

authors： Kowalski RP,Abdel Aziz S,Romanowski EG,Shanks RM,Nau AC,Raju LV

更新日期：2013-11-01 00:00:00

abstract：IMPORTANCE:Tuberculosis is an endemic infectious disease in developing countries. Patients receiving treatment for systemic tuberculosis may develop paradoxical growth of tuberculomas in the brain, which can lead to vision loss. OBSERVATIONS:We describe 3 patients who had paradoxical development of tuberculomas in the...

journal_title：JAMA ophthalmology

authors： Joseph M,Mendonca TM,Vasu U,Nithyanandam S,Mathew T

更新日期：2013-11-01 00:00:00

abstract：IMPORTANCE:We conducted a series of phase 1 clinical trials to elucidate the efficacy and safety of the selective Rho kinase inhibitor K-115 as a candidate drug for the treatment of glaucoma. We report the intraocular pressure (IOP)-lowering effects and safety of K-115 based on our results. OBJECTIVE:To study the IOP-...

journal_title：JAMA ophthalmology

authors： Tanihara H,Inoue T,Yamamoto T,Kuwayama Y,Abe H,Araie M,K-115 Clinical Study Group.

更新日期：2013-10-01 00:00:00

abstract：IMPORTANCE:Orbital lymphangiomas, congenital hamartomas of the lymphovascular tissue, are often associated with significant ocular complications and can be challenging to treat. To date, therapeutic approaches have demonstrated variable results and have significant ocular and systemic risks. We present 2 cases of pedia...

journal_title：JAMA ophthalmology

authors： Gandhi NG,Lin LK,O'Hara M

更新日期：2013-09-01 00:00:00

abstract：IMPORTANCE:Further research is crucial to better understand the reason for falls in individuals with visual impairment (VI) and to develop appropriate fall prevention strategies. OBJECTIVE:To compare balance measures in individuals with normal vision, VI, and uncorrected refractive error (URE). DESIGN AND SETTING:Cro...

journal_title：JAMA ophthalmology

authors： Willis JR,Vitale SE,Agrawal Y,Ramulu PY

更新日期：2013-08-01 00:00:00

abstract：IMPORTANCE:Accurate diagnosis of choroidal melanoma is challenging and has important implications for both physicians and patients. We assessed the utility of quantification of fundus autofluorescence in the evaluation and follow-up of choroidal nevomelanocytic tumors. OBJECTIVE:To assess the utility of autofluorescen...

journal_title：JAMA ophthalmology

authors： Albertus DL,Schachar IH,Zahid S,Elner VM,Demirci H,Jayasundera T

更新日期：2013-08-01 00:00:00

abstract：IMPORTANCE:Accurate assessment of disease burden and determination of disease progression are challenging in dry age-related macular degeneration (AMD). We assessed the utility of quantified fundus autofluorescence in (FAF) the evaluation and follow-up of dry AMD. OBJECTIVE:To develop a method for quantitative FAF ima...

journal_title：JAMA ophthalmology

authors： Schachar IH,Zahid S,Comer GM,Stem M,Schachar AG,Saxe SJ,Gardner TW,Elner VM,Jayasundera T

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of selective laser trabeculoplasty (SLT) for the treatment of primary open-angle glaucoma in an African-derived population in the developing world. METHODS:Sixty-one subjects from St. Lucia with medically treated primary open-angle glaucoma underwent a 30-day washout, followed by bil...

journal_title：JAMA ophthalmology

authors： Realini T

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To assess the benefit of increased follow-up and treatment with ranibizumab between months 24 and 36 in the Ranibizumab for Edema of the Macula in Diabetes (READ-2) Study. DESIGN:Prospective, interventional, multicenter follow-up of a randomized clinical trial. METHODS:Patients who agreed to participate bet...

journal_title：JAMA ophthalmology

authors： Do DV,Nguyen QD,Khwaja AA,Channa R,Sepah YJ,Sophie R,Hafiz G,Campochiaro PA,READ-2 Study Group.

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between vitreous fluid levels of inflammatory factors and macular edema in patients with branch retinal vein occlusion (BRVO). METHODS:In 39 patients with BRVO and macular edema and 21 individuals with idiopathic macular hole (MH) serving as controls, vitreous fluid samples were o...

journal_title：JAMA ophthalmology

authors： Noma H,Mimura T,Eguchi S

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy of WINROP (https://winrop.com), an algorithm based on serial measurements of neonatal body weight to predict proliferative retinopathy of prematurity (ROP), in a Korean population of preterm infants. METHODS:The records of preterm infants with gestational age less than 32 weeks wh...

journal_title：JAMA ophthalmology

authors： Choi JH,Löfqvist C,Hellström A,Heo H

更新日期：2013-01-01 00:00:00